ADP-Ribosyltransferases and Poly ADP-Ribosylation
نویسندگان
چکیده
منابع مشابه
The natural history of ADP-ribosyltransferases and the ADP-ribosylation system.
Catalysis of NAD(+)-dependent ADP-ribosylation of proteins, nucleic acids, or small molecules has evolved in at least three structurally unrelated superfamilies of enzymes, namely ADP-ribosyltransferase (ART), the Sirtuins, and probably TM1506. Of these, the ART superfamily is the most diverse in terms of structure, active site residues, and targets that they modify. The primary diversification...
متن کاملMammalian ADP-ribosyltransferases and ADP-ribosylhydrolases.
ADP-ribosyltransferases (ARTs) and ADP-ribosylhydrolases (ARHs) catalyze opposing reactions, which are termed ADP-ribosylation and de-ADP-ribosylation. ARTs transfer the ADP-ribose unit from NAD (nicotinamide adenine dinucleotide) onto an acceptor, while ARHs release the ADP-ribose from the target. Like protein phosphorylation, ADP-ribosylation is a posttranslational modification regulating pro...
متن کاملInhibiting poly(ADP-ribosylation) improves axon regeneration
The ability of a neuron to regenerate its axon after injury depends in part on its intrinsic regenerative potential. Here, we identify novel intrinsic regulators of axon regeneration: poly(ADP-ribose) glycohodrolases (PARGs) and poly(ADP-ribose) polymerases (PARPs). PARGs, which remove poly(ADP-ribose) from proteins, act in injured C. elegans GABA motor neurons to enhance axon regeneration. PAR...
متن کاملNew Facets in the Regulation of Gene Expression by ADP-Ribosylation and Poly(ADP-ribose) Polymerases
Ribosylation and Poly(ADP-ribose) Polymerases Keun Woo Ryu,†,‡,§,∥ Dae-Seok Kim,†,‡,∥ and W. Lee Kraus*,†,‡ †Laboratory of Signaling and Gene Regulation, Cecil H. and Ida Green Center for Reproductive Biology Sciences, ‡Division of Basic Research, Department of Obstetrics and Gynecology, and Graduate School of Biomedical Sciences, Program in Genetics and Development, University of Texas Southwe...
متن کاملReversing ADP-ribosylation
The modification of serines by molecules of ADP-ribose plays an important role in signaling that the DNA in a cell has been damaged and needs to be repaired.
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ژورنال
عنوان ژورنال: Current Protein & Peptide Science
سال: 2015
ISSN: 1389-2037
DOI: 10.2174/1389203716666150504122435